background: there are only four drugs for treating african trypanosomiasis, a devastating disease in sub-saharan africa. with slow discovery of better drugs, vaccination is viewed as the best method of control. we previously showed that antibodies to native trypanosoma brucei brucei tubulin inhibit the growth of trypanosomes in culture. here, we aimed to determine the effect of antibodies to ba...

Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a model system for antigenic variation, surviving by periodically replacing a monolayer of variant surface glycoproteins (VSG) that covers it...

Several investigations have used immunological techniques in elucidating the effect of host parasite relationship in animals to understand that of man. Sleeping sickness, a tropical disease in man is caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. The related species Trypanosoma brucei brucei causes Nagana disease and rapid death in domestic animals. Trypanosomiasis c...

This study was designed to determine the levels of parasitaemia on 20 healthy domesticated rabbit bucks infected with Trypanosoma brucei brucei over a period of eight weeks. Ten out of the 20 bucks were infected with 1 ml of the parasite containing 1 X 10 trypanosomes and known as infected group A, while the remaining ten bucks were left uninfected as group B. The infected bucks were monitored ...

We propose a new model for the Stumpy Induction Factor-induced slender to stumpy transformation of Trypanosoma brucei gambiense cells in immunosuppressed mice. The model is a set of delay differential equations that describe the time-course of the infection. We fit the model, using a maximum-likelihood method, to previously published data on parasitaemia in four mice. The model is shown to be a...

Plants with antimicrobial potential have been implicated in the treatment of infection. Studies shown that extracts from diverse plants antibacterial and or antitrypanosomal activities against infectious agents. This research work examined vitro testing ethanol extract Xylopia aethiopica Salmonella typhimurium Shigella species isolated wistar mouse already infected Trypanosoma evansi brucei bru...

Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In present work, we established a diagnostic ITS1-based PCR assay that allows detection of the DNA of all four Trypanosoma brucei subspecies (Trypanosoma brucei br...

Eine Struktur-Aktivitäts-Beziehung des Naturstoffs Leucinostatin A führte zu zwei hochpotenten Verbindungen gegen das Protozoon Trypanosoma brucei mit verminderter toxischer Wirkung in vitro und vivo. Diese bildeten keine Resistenzen bei langzeitiger subletaler Exposition ihr Wirkmechanismus liegt der Destabilisierung inneren Mitochondrienmembran.

Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively...

Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the ...